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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CLC4 Antibody (C-term)   

CLC4 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CLC4 Antibody (C-term) AP6329f
    Western blot of chicken brain tissue incubated with CLC4 Antibody (C-term) (Cat.# AP6329f). Data courtesy of Emily McMains, Louisiana State University.
  • IF - CLC4 Antibody (C-term) AP6329f
    Immunofluorescence image of cultured chick retinal amacrine (neuronal) cells labeled with CLC4 Antibody (C-term) (Cat # AP6329f). Data courtesy of Emily McMains, Louisiana State University.
  • IHC-P - CLC4 Antibody (C-term) AP6329f
    Retinae were collected from adult White Leghorn chicken and fixed in the eyecup for two hours in 4% Paraformaldehyde (in PBS). Retinae were then removed from the eyecups and incubated in 30% sucrose (in PBS) overnight. Retinal tissue was embedded and frozen in OCT compound and cut into ~15um sections on a cryotome. Sections were blocked in 5% normal goat serum (in 1%BSA/.1%saponin PBS) for one hour and then incubated at RT with 1:250 (1%BSA/.1% saponin PBS) ClC4 antibody (Cat.# AP6329f) for 1 hour. Sections were then washed in PBS (3X10minutes) and then treated with secondary antibody (1:500 Cy3) for one hour. After another PBS wash series, sections were coverslipped and antibody labeling was visualized at 20X with a Leica upright microscope using a TRITC filter set and Xenon lamp illumination. (Crousillac et al, 2003)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51793
Other Accession P51794, Q61418
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 84917 Da
Antigen Region 663-689 aa
Additional Information
Gene ID 1183
Other Names H(+)/Cl(-) exchange transporter 4, Chloride channel protein 4, ClC-4, Chloride transporter ClC-4, CLCN4
Target/Specificity This CLC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-689 amino acids from the C-terminal region of human CLC4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCLC4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLCN4
Function Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.
Cellular Location Early endosome membrane {ECO:0000250|UniProtKB:P51794}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51794}. Late endosome membrane {ECO:0000250|UniProtKB:P51794}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51794}. Endoplasmic reticulum membrane
Tissue Location Abundant in skeletal muscle and also detectable in brain and heart
Research Areas
Citations (0)

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The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders.


Wang, T., et al., Gastroenterology 126(4):1157-1166 (2004).
Lamb, F.S., et al., J. Mol. Cell. Cardiol. 31(3):657-666 (1999).
Dinulos, M.B., et al., Genomics 35(1):244-247 (1996).
Schnur, R.E., et al., Hum. Genet. 95(5):594-595 (1995).
van Slegtenhorst, M.A., et al., Hum. Mol. Genet. 3(4):547-552 (1994).

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Cat# AP6329f
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