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IGJ Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - IGJ Antibody (N-term) AP6548a
    Western blot analysis of IGJ antibody (N-term) (Cat.# AP6548a) in mouse spleen lysates (35ug/lane). IGJ (arrow) was detected using the purified Pab.
  • IHC-P - IGJ Antibody (N-term) AP6548a
    Formalin-fixed and paraffin-embedded mouse spleen reacted with IGJ Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - IGJ Antibody (N-term) AP6548a
    IGJ Antibody (N-term) (Cat. #AP6548a) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01591
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 32-61 aa
Additional Information
Other Names Immunoglobulin J chain, IGJ, IGCJ
Target/Specificity This IGJ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human IGJ.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIGJ Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name JCHAIN (HGNC:5713)
Synonyms IGCJ, IGJ
Function Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
Cellular Location Secreted {ECO:0000250|UniProtKB:P01592}. EMBL; AK312014; BAG34952.1; -; mRNA EMBL; M12759; AAA58902.1; -; Genomic_DNA EMBL; M12378; AAA58902.1; JOINED; Genomic_DNA CCDS; CCDS3545.1; - PIR; A01859; JIHU RefSeq; NP_653247.1; NM_144646.3 RefSeq; XP_006714274.1; XM_006714211.2 RefSeq; XP_006714275.1; XM_006714212.2 RefSeq; XP_011530227.1; XM_011531925.1 RefSeq; XP_011530228.1; XM_011531926.1 UniGene; Hs.643431; - ProteinModelPortal; P01591; - BioGrid; 109732; 24 IntAct; P01591; 5 MINT; P01591; - STRING; 9606.ENSP00000254801; - GlyConnect; 277; - iPTMnet; P01591; - PhosphoSitePlus; P01591; - UniCarbKB; P01591; - BioMuta; JCHAIN; - SWISS-2DPAGE; P01591; - EPD; P01591; - jPOST; P01591; - MaxQB; P01591; - PaxDb; P01591; - PeptideAtlas; P01591; - PRIDE; P01591; - ProteomicsDB; 51394; - Ensembl; ENST00000254801; ENSP00000254801; ENSG00000132465 Ensembl; ENST00000510437; ENSP00000426687; ENSG00000132465 Ensembl; ENST00000543780; ENSP00000440066; ENSG00000132465 GeneID; 3512; - KEGG; hsa:3512; - UCSC; uc003hfn.5; human CTD; 3512; - DisGeNET; 3512; - EuPathDB; HostDB:ENSG00000132465.10; - GeneCards; JCHAIN; - HGNC; HGNC:5713; JCHAIN HPA; CAB034436; - HPA; HPA044132; - MIM; 147790; gene neXtProt; NX_P01591; - OpenTargets; ENSG00000132465; - PharmGKB; PA29733; - eggNOG; ENOG410IYAZ; Eukaryota eggNOG; ENOG410YX96; LUCA GeneTree; ENSGT00390000012791; - HOGENOM; HOG000113012; - HOVERGEN; HBG006138; - InParanoid; P01591; - OMA; KCYTNRV; - OrthoDB; 665362at2759; - PhylomeDB; P01591; - TreeFam; TF335878; - Reactome; R-HSA-202733; Cell surface interactions at the vascular wall Reactome; R-HSA-2168880; Scavenging of heme from plasma ChiTaRS; JCHAIN; human GeneWiki; IGJ; - GenomeRNAi; 3512; - PRO; PR:P01591; - Proteomes; UP000005640; Chromosome 4 Bgee; ENSG00000132465; Expressed in 169 organ(s), highest expression level in caecum ExpressionAtlas; P01591; baseline and differential Genevisible; P01591; HS GO; GO:0072562; C:blood microparticle; HDA:UniProtKB GO; GO:0071750; C:dimeric IgA immunoglobulin complex; IMP:UniProtKB GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB GO; GO:0005576; C:extracellular region; TAS:Reactome GO; GO:0005615; C:extracellular space; IDA:UniProtKB GO; GO:0071748; C:monomeric IgA immunoglobulin complex; IDA:UniProtKB GO; GO:0071756; C:pentameric IgM immunoglobulin complex; IDA:UniProtKB GO; GO:0071752; C:secretory dimeric IgA immunoglobulin complex; IDA:UniProtKB GO; GO:0071751; C:secretory IgA immunoglobulin complex; IDA:UniProtKB GO; GO:0003823; F:antigen binding; NAS:UniProtKB GO; GO:0019862; F:IgA binding; IMP:UniProtKB GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central GO; GO:0030674; F:protein binding, bridging; IEA:Ensembl GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB GO; GO:0002250; P:adaptive immune response; IDA:UniProtKB GO; GO:0019731; P:antibacterial humoral response; IDA:UniProtKB GO; GO:0003094; P:glomerular filtration; IMP:UniProtKB GO; GO:0006955; P:immune response; NAS:UniProtKB GO; GO:0045087; P:innate immune response; IDA:UniProtKB GO; GO:0050900; P:leukocyte migration; TAS:Reactome GO; GO:0032461; P:positive regulation of protein oligomerization; IMP:UniProtKB GO; GO:0060267; P:positive regulation of respiratory burst; IDA:UniProtKB GO; GO:0006898; P:receptor-mediated endocytosis; TAS:Reactome GO; GO:0001895; P:retina homeostasis; HEP:UniProtKB InterPro; IPR024110; Ig_J PANTHER; PTHR10070; PTHR10070; 1 Pfam; PF15097; Ig_J_chain; 1 ProDom; PD021296; PD021296; 1 1: Evidence at protein level; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal SIGNAL 1 22 CHAIN 23 159 Immunoglobulin J chain /FTId=PRO_0000084174 MOD_RES 23 23 Pyrrolidone carboxylic acid CARBOHYD 71 71 N-linked (GlcNAc...) (complex) asparagine. /FTId=CAR_000167 DISULFID 35 123 DISULFID 37 37 Interchain (with heavy chain) DISULFID 91 91 Interchain (with heavy chain) DISULFID 94 114 DISULFID 131 156 SEQUENCE 159 AA; 18099 MW; B7835C02CCC0CB05 CRC64; MKNHLLFWGV LAVFIKAVHV KAQEDERIVL VDNKCKCARI TSRIIRSSED PNEDIVERNI RIIVPLNNRE NISDPTSPLR TRFVYHLSDL CKKCDPTEVE LDNQIVTATQ SNICDEDSAT ETCYTYDRNK CYTAVVPLVY GGETKMVETA LTPDACYPD
Research Areas
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IGJ serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.


Ramachandran,P., J. Proteome Res. 5 (6), 1493-1503 (2006)
Liu,T., J. Proteome Res. 4 (6), 2070-2080 (2005)

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Cat# AP6548a
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