|Application ||WB, IHC-P, E|
|Calculated MW||43405 Da|
|Antigen Region||7-34 aa|
|Other Names||Diphosphomevalonate decarboxylase, Mevalonate (diphospho)decarboxylase, MDDase, Mevalonate pyrophosphate decarboxylase, MVD, MPD|
|Target/Specificity||This MVD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-34 amino acids from the N-terminal region of human MVD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MVD Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Performs the first committed step in the biosynthesis of isoprenes.|
|Tissue Location||Expressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP.
Voynova,N.E., Arch. Biochem. Biophys. 480 (1), 58-67 (2008)
Hogenboom,S., Mol. Genet. Metab. 81 (3), 216-224 (2004)
Wadhwa,R., Biochem. Biophys. Res. Commun. 302 (4), 735-742 (2003)
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