- CITATIONS: 4
|Application ||WB, IHC-P, E|
|Calculated MW||133353 Da|
|Antigen Region||1155-1187 aa|
|Other Names||Myotubularin-related protein 4, FYVE domain-containing dual specificity protein phosphatase 2, FYVE-DSP2, Zinc finger FYVE domain-containing protein 11, MTMR4, KIAA0647, ZFYVE11|
|Target/Specificity||This MTMR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1155-1187 amino acids from the C-terminal region of human MTMR4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MTMR4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized to perinuclear region|
|Tissue Location||Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow|
Provided below are standard protocols that you may find useful for product applications.
MTMR, a member of the myotubularin family, encodes an intracellular protein of 1,195 amino acids, and shares approximately 47% sequence identity with MTMR3, spiking to over 70% identity in the catalytic domain and the double zinc finger (FYVE) motif. PCR analysis detects expression of MTMR4 in all human tissues examined except lung, small intestine, stomach, salivary gland, adrenal gland, and uterus. Subcellular localization of MTMR4 in transfected HeLa cells showed a perinuclear distribution, similar to that seen with MTMR3. MTMR4 dephosphorylates para-nitrophenylphosphate and phosphatidylinositol 3-phosphate.
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