|Application ||WB, IHC-P, E|
|Other Accession||P42893, Q4PZA2, P42891|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||87164 Da|
|Antigen Region||391-420 aa|
|Other Names||Endothelin-converting enzyme 1, ECE-1, ECE1|
|Target/Specificity||This ECE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the Central region of human ECE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ECE1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Converts big endothelin-1 to endothelin-1.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney.|
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Provided below are standard protocols that you may find useful for product applications.
ECE-1 is involved in proteolytic processing of endothelin precursors to biologically active peptides.
Cottrell,G.S., et.al., J. Biol. Chem. 284 (33), 22411-22425 (2009)
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