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WNK3 (PRKWNK3) Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - WNK3 (PRKWNK3) Antibody (C-term) AP7054b
    PRKWNK3 Antibody (Cat. #AP7054b) western blot analysis in uterus tumor cell line lysates (35ug/lane).This demonstrates the PRKWNK3 antibody detected the PRKWNK3 protein (arrow).
  • IHC-P - WNK3 (PRKWNK3) Antibody (C-term) AP7054b
    WNK3(PRKWNK3) Antibody (C-term) (Cat. #AP7054b)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of WNK3(PRKWNK3) Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BYP7
Other Accession Q9BYP7-2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 198416 Da
Antigen Region 1586-1616 aa
Additional Information
Gene ID 65267
Other Names Serine/threonine-protein kinase WNK3, Protein kinase lysine-deficient 3, Protein kinase with no lysine 3, WNK3, KIAA1566, PRKWNK3
Target/Specificity This WNK3 (PRKWNK3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1586-1616 amino acids from the C-terminal region of human WNK3 (PRKWNK3).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsWNK3 (PRKWNK3) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WNK3 (HGNC:14543)
Function Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011). Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.
Cellular Location Cytoplasm.
Tissue Location Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Isoform 1 is brain- specific. Isoform 3 is kidney-specific
Research Areas
Citations (0)

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Members of the 'with no lysine' (WNK) kinase family, such as WNK3, are serine-threonine protein kinases that lack the almost invariant catalytic lysine in subdomain II, which is important for binding ATP in the catalytic site. Instead, these kinases have a conserved lysine in subdomain I that is thought to provide this function (Holden et al., 2004 [PubMed 15194194]).[supplied by OMIM]


Verissimo, F., et al., Oncogene 20(39):5562-5569 (2001).
Nagase, T., et al., DNA Res. 7(4):273-281 (2000).

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$ 325.00
$ 109.00
Cat# AP7054b
Availability: In Stock
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