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MKNK1 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MKNK1 Antibody (N-term) AP7151a
    The anti-MKNK1 Pab (Cat. #AP7151a) is used in Western blot to detect MKNK1 in A2058 tissue lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BUB5
Other Accession O08605
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51342 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 8569
Other Names MAP kinase-interacting serine/threonine-protein kinase 1, MAP kinase signal-integrating kinase 1, MAPK signal-integrating kinase 1, Mnk1, MKNK1, MNK1
Target/Specificity This MKNK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MKNK1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMKNK1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MKNK1
Synonyms MNK1
Function May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7- methylguanosine-containing mRNA cap.
Cellular Location Isoform 2: Cytoplasm.
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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MKNK1 encodes a predicted 424-amino acid protein containing a sequence typical of the catalytic domain of serine/threonine kinases and a putative N-terminal nuclear localization signal sequence.C-terminal region of MKNK1 was phosphorylated and activated in vivo and in vitro by ERK1 and p38 MAP kinases, but not by JNK/SAPK. The activated ERK is essential for the activation of MKNK1 in insect cells. MKNK1 was activated following stimulation of HeLa cells with a variety of extracellular stimuli. MNK1 bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2, and also binds strongly to the stress-activated kinase, p38.


Orton, K.C., et al., J. Biol. Chem. 279(37):38649-38657 (2004).
Cuesta, R., et al., J. Virol. 78(14):7707-7716 (2004).
Knauf, U., et al., Mol. Cell. Biol. 21(16):5500-5511 (2001).
Cuesta, R., et al., Genes Dev. 14(12):1460-1470 (2000).
Fukunaga, R., et al., EMBO J. 16(8):1921-1933 (1997).

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$ 325.00
$ 109.00
Cat# AP7151a
Availability: In Stock
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