|Application ||FC, IHC-P, WB, E|
|Other Accession||Q9QYG8, Q99PM9|
|Calculated MW||29299 Da|
|Antigen Region||227-255 aa|
|Other Names||Uridine-cytidine kinase 2, UCK 2, Cytidine monophosphokinase 2, Testis-specific protein TSA903, Uridine monophosphokinase 2, UCK2, UMPK|
|Target/Specificity||This UCK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-255 amino acids from the C-terminal region of human UCK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UCK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine.|
|Tissue Location||According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
UCK2 catalyzes the phosphorylation of uridine monophosphate to uridine diphosphate. This is the first step in the production of the pyrimidine nucleoside triphosphates required for RNA and DNA synthesis. In addition, an allele of this gene may play a role in mediating nonhumoral immunity to Hemophilus influenzae type B.
Murata, D., et al., Drug Metab. Dispos. 32(10):1178-1182 (2004).
Pasti, C., et al., Eur. J. Biochem. 270(8):1784-1790 (2003).
Liou, J.Y., et al., Cancer Res. 62(6):1624-1631 (2002).
Pearman, A.T., et al., Life Sci. 69(20):2361-2370 (2001).
Van Rompay, A.R., et al., Mol. Pharmacol. 56(3):562-569 (1999).
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