|Application ||WB, IHC-P, FC, E|
|Calculated MW||37895 Da|
|Antigen Region||271-299 aa|
|Other Names||Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, NAD-dependent methylenetetrahydrofolate dehydrogenase, Methenyltetrahydrofolate cyclohydrolase, MTHFD2, NMDMC|
|Target/Specificity||This MTHFD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-299 amino acids from the C-terminal region of human MTHFD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MTHFD2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.|
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Provided below are standard protocols that you may find useful for product applications.
MTHFD2 is a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD.
Wang,S.S., Leukemia 23 (3), 596-602 (2009)
Pawelek,P.D., Biochemistry 37 (4), 1109-1115 (1998)
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