|Application ||IHC-P, WB, E|
|Calculated MW||143720 Da|
|Antigen Region||1256-1287 aa|
|Other Names||Insulin receptor-related protein, IRR, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain, INSRR, IRR|
|Target/Specificity||This Insulin Receptor R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1256-1287 amino acids from the C-terminal region of human Insulin Receptor R.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Insulin Receptor R Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
Shier, P., et al., J. Biol. Chem. 264(25):14605-14608 (1989).
Whitmore, T.E., et al., Cytogenet. Cell Genet. 87 (1-2), 93-94 (1999).
Hanze, J., et al., Horm. Metab. Res. 31 (2-3), 77-79 (1999).
Shier, P., et al., Cytogenet. Cell Genet. 54 (1-2), 80-81 (1990).
Elmlinger, M.W., et al., Regul. Pept. 84 (1-3), 37-42 (1999).
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