|Application ||WB, IHC-P, IF, E|
|Calculated MW||12447 Da|
|Antigen Region||8-34 aa|
|Other Names||Somatoliberin, Growth hormone-releasing factor, GRF, Growth hormone-releasing hormone, GHRH, Somatocrinin, Somatorelin, Sermorelin, GHRH, GHRF|
|Target/Specificity||This GHRH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-34 amino acids from the N-terminal region of human GHRH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GHRH Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.|
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Provided below are standard protocols that you may find useful for product applications.
GHRH belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this protein are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism.
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