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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GNA12 Antibody (S67)   

GNA12 Antibody (S67)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GNA12 Antibody (S67) AP8035a
    All lanes : Anti-GNA12 Antibody (S67) at 1:1000 dilution Lane 1: A2058 whole cell lysate Lane 2: MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 44 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q03113
Other Accession P25157, Q6Q7Y5, P27601, Q14344, Q63210, P27600, Q5YKG4
Reactivity Human
Predicted Zebrafish, Mouse, Rat, Drosophila
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 44279 Da
Antigen Region 46-75 aa
Additional Information
Gene ID 2768
Other Names Guanine nucleotide-binding protein subunit alpha-12, G alpha-12, G-protein subunit alpha-12, GNA12
Target/Specificity This GNA12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from human GNA12.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGNA12 Antibody (S67) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GNA12
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1- mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).
Cellular Location Cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q63210}. Lateral cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q63210}. Cytoplasm. Note=CDH1 enhances cell membrane localization.
Research Areas
Citations (0)

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Guanine nucleotide-binding proteins (G proteins) are modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 subunits; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.


Krakstad, B.F., et al., Proc. Natl. Acad. Sci. U.S.A. 101(28):10314-10319 (2004).
Hillier, L.W., et al., Nature 424(6945):157-164 (2003).
Scherer, S.W., et al., Science 300(5620):767-772 (2003).
Suzuki, N., et al., Proc. Natl. Acad. Sci. U.S.A. 100(2):733-738 (2003).
Yamaguchi, Y., et al., J. Biol. Chem. 278(17):14936-14939 (2003).

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$ 325.00
$ 109.00
Cat# AP8035a
Availability: In Stock
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