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Urokinase (PLAU) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Urokinase (PLAU) Antibody (C-term) AP8161B
    Western blot analysis of anti-PLAU Pab (Cat. #AP8161b) in CEM cell line lysate (35ug/lane). PLAU(arrow) was detected using the purified Pab
  • IHC-P - Urokinase (PLAU) Antibody (C-term) AP8161B
    Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with PLAU antibody (C-term ), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • IF - Urokinase (PLAU) Antibody (C-term) AP8161B
    Confocal immunofluorescent analysis of Urokinase (PLAU) Antibody (C-term)(Cat#AP8161b) with A2058 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
  • FC - Urokinase (PLAU) Antibody (C-term) AP8161B
    Urokinase (PLAU) Antibody (C-term) (Cat. #AP8161a) flow cytometric analysis of A2058 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P00749
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 48507 Da
Antigen Region 396-426 aa
Additional Information
Gene ID 5328
Other Names Urokinase-type plasminogen activator, U-plasminogen activator, uPA, Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A, Urokinase-type plasminogen activator chain B, PLAU
Target/Specificity This Urokinase (PLAU) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-426 amino acids from the C-terminal region of human Urokinase (PLAU).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUrokinase (PLAU) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Cellular Location Secreted.
Tissue Location Expressed in the prostate gland and prostate cancers.
Research Areas
Citations (0)

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PLAU, a member of the peptidase family S1, is a potent plasminogen activator and is clinically used for therapy of thrombolytic disorders. PLAU specifically cleaves the Arg-|-Val bond in plasminogen to form plasmin. The protein is found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A. Cleavage occurs after residue 155 in the low molecular mass form to yield a short A1 chain. The protein is used in Pulmonary Embolism (PE) to initiates fibrinolysis. Structurally, PLAU contains 1 EGF-like domain and 1 kringle domain.


Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
Sperl, S., et al., Proc. Natl. Acad. Sci. U.S.A. 97(10):5113-5118 (2000).
Turkmen, B., et al., Electrophoresis 18(5):686-689 (1997).
Conne, B., et al., Thromb. Haemost. 77(3):434-435 (1997).
Yoshimoto, M., et al., Biochim. Biophys. Acta 1293(1):83-89 (1996).

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Cat# AP8161B
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