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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Guanylyl Cyclase alpha 2 (GUCY1A2) Antibody (C-term)   

Guanylyl Cyclase alpha 2 (GUCY1A2) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Guanylyl Cyclase alpha 2 (GUCY1A2) Antibody (C-term) AP8176b
    Western blot analysis of anti-GUCY1A2 Antibody (C-term) (Cat.#AP8176b) in NCI-H460 cell line lysates (35ug/lane). GUCY1A2 (arrow) was detected using the purified Pab.
  • IHC-P - Guanylyl Cyclase alpha 2 (GUCY1A2) Antibody (C-term) AP8176b
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P33402
Other Accession Q9WVI4, NP_000846
Reactivity Human
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 81750 Da
Antigen Region 699-732 aa
Additional Information
Gene ID 2977
Other Names Guanylate cyclase soluble subunit alpha-2, GCS-alpha-2, GUCY1A2, GUC1A2, GUCSA2
Target/Specificity This Guanylyl Cyclase alpha 2 (GUCY1A2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 699-732 amino acids from the C-terminal region of human Guanylyl Cyclase alpha 2 (GUCY1A2).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGuanylyl Cyclase alpha 2 (GUCY1A2) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GUCY1A2
Synonyms GUC1A2, GUCSA2
Function Has guanylyl cyclase on binding to the beta-1 subunit.
Cellular Location Cytoplasm.
Tissue Location Isoform 1 is expressed in fetal brain, liver, colon, endothelium and testis. Isoform 2 is expressed only in liver, colon and endothelium
Research Areas
Citations (0)

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Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.


Baba, H., et al., Neuroreport 15(4):677-680 (2004).
Bellamy, T.C., et al., Proc. Natl. Acad. Sci. U.S.A. 99(1):507-510 (2002).
Russwurm, M., et al., J. Biol. Chem. 276(48):44647-44652 (2001).
Bamberger, A.M., et al., J. Clin. Endocrinol. Metab. 86(2):909-912 (2001).
Budworth, J., et al., Biochem. Biophys. Res. Commun. 263(3):696-701 (1999).

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Cat# AP8176b
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