|Application ||WB, IHC-P, E|
|Other Accession||P20651, P48453|
|Calculated MW||59024 Da|
|Antigen Region||1-30 aa|
|Other Names||Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit beta isoform, PPP3CB, CALNA2, CALNB, CNA2|
|Target/Specificity||This PPP3CB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PPP3CB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPP3CB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CALNA2, CALNB, CNA2|
|Function||Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:26794871). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
PPP3CB is a calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
Katanosaka, Y., et al., J. Biol. Chem. 280(7):5764-5772 (2005).
Bell, O., et al., Mol. Endocrinol. 19(2):516-526 (2005).
Bennasser, Y., et al., Virology 303(1):174-180 (2002).
Kissinger, C.R., et al., Nature 378(6557):641-644 (1995).
Muramatsu, T., et al., Biochim. Biophys. Acta 1178(1):117-120 (1993).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.