- CITATIONS: 2
|Application ||IHC-P, WB, E|
|Calculated MW||107188 Da|
|Antigen Region||792-819 aa|
|Other Names||Anoctamin-5, Gnathodiaphyseal dysplasia 1 protein, Transmembrane protein 16E, ANO5, GDD1, TMEM16E|
|Target/Specificity||This ANO5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 792-819 amino acids from the C-terminal region of human ANO5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ANO5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Does not exhibit calcium-activated chloride channel (CaCC) activity.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Colocalized with CALR/calreticulin (PubMed:15124103). Shows an intracellular localization according to PubMed:22075693.|
|Tissue Location||Highly expressed in brain, heart, kidney, lung, and skeletal muscle. Weakly expressed in bone marrow, fetal liver, placenta, spleen, thymus, osteoblasts and periodontal ligament cells.|
Provided below are standard protocols that you may find useful for product applications.
ANO5 is a member of the anoctamin family of transmembrane proteins. This protein is likely a calcium activated chloride channel.
Katoh,M. et.al., Am. J. Hum. Genet. 75 (5), 927-928 (2004)
Tsutsumi,S., et.al., Am. J. Hum. Genet. 74 (6), 1255-1261 (2004)
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