|Application ||WB, IHC-P, E|
|Calculated MW||64473 Da|
|Antigen Region||325-354 aa|
|Other Names||Folliculin, BHD skin lesion fibrofolliculoma protein, Birt-Hogg-Dube syndrome protein, FLCN, BHD|
|Target/Specificity||This FLCN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-354 amino acids from the Central region of human FLCN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FLCN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.|
|Cellular Location||Cytoplasm. Nucleus Note=Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm.|
|Tissue Location||Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
FLCN may play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). FLCN may be a tumor suppressor. May be involved in colorectal tumorigenesis. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways.
Khoo,S.K., et.al., J. Med. Genet. 39 (12), 906-912 (2002)
Shin,J.H., et.al., J. Med. Genet. 40 (5), 364-367 (2003)
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