|Application ||WB, IHC-P, FC, E|
|Calculated MW||27567 Da|
|Antigen Region||191-218 aa|
|Other Names||Derlin-2, Degradation in endoplasmic reticulum protein 2, DERtrin-2, Der1-like protein 2, F-LAN-1, F-LANa, DERL2, DER2, FLANA|
|Target/Specificity||This DERL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-218 amino acids from the C-terminal region of human DERL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DERL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins (PubMed:16186509, PubMed:16449189). May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908).|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein|
|Tissue Location||Ubiquitous. Overexpressed in various hepatocarcinomas.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER.
Lilley,B.N.et.al., Nature 429 (6994), 834-840 (2004)
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