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NEURL Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NEURL Antibody (Center) AP8737c
    Anti-NEURL Antibody (Center) at 1:1000 dilution + Y79 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 62 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - NEURL Antibody (Center) AP8737c
    Western blot analysis of NEURL Antibody (Center) (Cat. #AP8737c) in Y79 cell line lysates (35ug/lane). NEURL (arrow) was detected using the purified Pab.
  • IHC-P - NEURL Antibody (Center) AP8737c
    Formalin-fixed and paraffin-embedded human brain tissue reacted with NEURL Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O76050
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 61860 Da
Antigen Region 158-186 aa
Additional Information
Gene ID 9148
Other Names E3 ubiquitin-protein ligase NEURL1, 632-, Neuralized-like protein 1A, h-neu, h-neuralized 1, RING finger protein 67, NEURL1, NEURL, NEURL1A, RNF67
Target/Specificity This NEURL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-186 amino acids from the Central region of human NEURL.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNEURL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NEURL, NEURL1A, RNF67
Function Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
Cellular Location Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein Perikaryon. Cell projection, dendrite Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity) Colocalized with JAG1 at the cell surface.
Tissue Location Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues.
Research Areas
Citations (0)

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NEURL is involved in the determination of cell fate in the neurogenic region of the embryo and plays a role in the determination of cell fate in the central nervous system. NEURL may act as a tumor suppressor whose inactivation could be associated with malignant progression of astrocytic tumors.


Kile,B.T.,, Trends Biochem. Sci. 27 (5), 235-241 (2002)

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$ 325.00
$ 109.00
Cat# AP8737c
Availability: In Stock
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