|Application ||WB, IHC-P, FC, E|
|Other Accession||P24807, NP_037362|
|Calculated MW||8083 Da|
|Antigen Region||1-30 aa|
|Other Names||Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, CD24, CD24, CD24A|
|Target/Specificity||This CD24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CD24.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD24 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor.|
|Tissue Location||B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CD24 is a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. This protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface.
Kay,R., et.al., J. Immunol. 147 (4), 1412-1416 (1991)
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