|Application ||WB, FC, E|
|Calculated MW||41044 Da|
|Antigen Region||291-318 aa|
|Other Names||C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR-3, CCR3, CKR3, Eosinophil eotaxin receptor, CD193, CCR3, CMKBR3|
|Target/Specificity||This CCR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-318 amino acids from the Central region of human CCR3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCR3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||In eosinophils as well as trace amounts in neutrophils and monocytes|
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Provided below are standard protocols that you may find useful for product applications.
CCR3 is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1.
Ponath,P.D., et.al., J. Clin. Invest. 97 (3), 604-612 (1996)
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