|Application ||WB, FC, E|
|Calculated MW||126655 Da|
|Antigen Region||861-888 aa|
|Other Names||Potassium voltage-gated channel subfamily H member 2, Eag homolog, Ether-a-go-go-related gene potassium channel 1, ERG-1, Eag-related protein 1, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1, Voltage-gated potassium channel subunit Kv111, KCNH2, ERG, ERG1, HERG|
|Target/Specificity||This KCNH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 861-888 amino acids from the Central region of human KCNH2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNH2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ERG, ERG1, HERG|
|Function||Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661).|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
|Tissue Location||Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells|
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Provided below are standard protocols that you may find useful for product applications.
KCNH2 is a voltage-activated potassium channel belonging to the eag family.
Trudeau,M.C., et.al., Science 269 (5220), 92-95 (1995)
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