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CSRP2BP Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CSRP2BP Antibody (Center) AP8865c
    Western blot analysis of CSRP2BP Antibody (Center) (Cat. #AP8865c) in Y79, A2058, A375, MDA-MB231 cell line lysates (35ug/lane). CSRP2BP (arrow) was detected using the purified Pab.
  • IHC-P - CSRP2BP Antibody (Center) AP8865c
    Formalin-fixed and paraffin-embedded human skeletal muscle reacted with CSRP2BP Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9H8E8
Other Accession Q8CID0
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 246-275 aa
Additional Information
Other Names Cysteine-rich protein 2-binding protein, CSRP2-binding protein, ADA2A-containing complex subunit 2, ATAC2, CRP2-binding partner, CRP2BP, CSRP2BP
Target/Specificity This CSRP2BP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 246-275 amino acids from the Central region of human CSRP2BP.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCSRP2BP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KAT14 (HGNC:15904)
Synonyms CSRP2BP
Function Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.
Cellular Location Nucleus. Cytoplasm. Note=Mainly nuclear.
Tissue Location Expressed in skeletal muscle, heart, lung, placenta, brain, liver, pancreas and kidney. High expression in skeletal muscle and heart. Lower expression in lung EMBL; AK023759; BAB14669.1; -; mRNA EMBL; AL050321; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471133; EAX10255.1; -; Genomic_DNA EMBL; BC007537; AAH07537.1; -; mRNA EMBL; BC009174; -; NOT_ANNOTATED_CDS; mRNA EMBL; AF252257; AAG10249.1; -; mRNA CCDS; CCDS13133.1; -. [Q9H8E8-1] RefSeq; NP_065397.3; NM_020536.4 UniGene; Hs.488051; - UniGene; Hs.728790; - ProteinModelPortal; Q9H8E8; - BioGrid; 121485; 36 ComplexPortal; CPX-1004; PCAF-containing ATAC complex ComplexPortal; CPX-997; GCN5-containing ATAC complex CORUM; Q9H8E8; - IntAct; Q9H8E8; 13 MINT; Q9H8E8; - STRING; 9606.ENSP00000278816; - iPTMnet; Q9H8E8; - PhosphoSitePlus; Q9H8E8; - BioMuta; KAT14; - DMDM; 308153608; - EPD; Q9H8E8; - jPOST; Q9H8E8; - MaxQB; Q9H8E8; - PaxDb; Q9H8E8; - PeptideAtlas; Q9H8E8; - PRIDE; Q9H8E8; - ProteomicsDB; 81203; - ProteomicsDB; 81204; -. [Q9H8E8-2] DNASU; 57325; - Ensembl; ENST00000435364; ENSP00000392318; ENSG00000149474. [Q9H8E8-1] Ensembl; ENST00000489634; ENSP00000425909; ENSG00000149474. [Q9H8E8-2] GeneID; 57325; - KEGG; hsa:57325; - UCSC; uc002wqk.3; human. [Q9H8E8-1] CTD; 57325; - DisGeNET; 57325; - EuPathDB; HostDB:ENSG00000149474.13; - GeneCards; KAT14; - HGNC; HGNC:15904; KAT14 HPA; CAB034224; - HPA; HPA068443; - MIM; 617501; gene neXtProt; NX_Q9H8E8; - OpenTargets; ENSG00000149474; - PharmGKB; PA26969; - eggNOG; ENOG410IQJZ; Eukaryota eggNOG; ENOG410Y6C7; LUCA GeneTree; ENSGT00390000001146; - HOGENOM; HOG000230880; - HOVERGEN; HBG051142; - InParanoid; Q9H8E8; - OMA; DCSEDGK; - OrthoDB; 1404086at2759; - PhylomeDB; Q9H8E8; - TreeFam; TF324809; - BRENDA; 2.3.1.48; 2681 Reactome; R-HSA-3214847; HATs acetylate histones GeneWiki; CSRP2BP; - GenomeRNAi; 57325; - PRO; PR:Q9H8E8; - Proteomes; UP000005640; Chromosome 20 Bgee; ENSG00000149474; Expressed in 192 organ(s), highest expression level in frontal cortex ExpressionAtlas; Q9H8E8; baseline and differential Genevisible; Q9H8E8; HS GO; GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IDA:BHF-UCL GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:0005634; C:nucleus; IPI:UniProtKB GO; GO:0004402; F:histone acetyltransferase activity; IDA:MGI GO; GO:0030274; F:LIM domain binding; NAS:UniProtKB GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IEA:Ensembl GO; GO:0016573; P:histone acetylation; IBA:GO_Central GO; GO:0043966; P:histone H3 acetylation; IDA:BHF-UCL InterPro; IPR016181; Acyl_CoA_acyltransferase InterPro; IPR000182; GNAT_dom InterPro; IPR037829; KAT14 PANTHER; PTHR20916:SF0; PTHR20916:SF0; 1 Pfam; PF13673; Acetyltransf_10; 1 SUPFAM; SSF55729; SSF55729; 1 PROSITE; PS51186; GNAT; 1 1: Evidence at protein level; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome CHAIN 1 782 Cysteine-rich protein 2-binding protein /FTId=PRO_0000074603 DOMAIN 638 782 N-acetyltransferase {ECO:0000255|PROSITE-ProRule:PRU00532} MOD_RES 4 4 Phosphoserine MOD_RES 231 231 N6-acetyllysine {ECO:0000250|UniProtKB:Q8CID0} MOD_RES 285 285 Phosphoserine MOD_RES 292 292 N6-acetyllysine MOD_RES 416 416 Phosphoserine VAR_SEQ 1 128 Missing (in isoform 2) /FTId=VSP_000070 VARIANT 214 214 P -> L (in dbSNP:rs6081011) /FTId=VAR_028034 VARIANT 400 400 V -> G (in dbSNP:rs1205193) /FTId=VAR_028035 VARIANT 442 442 R -> T (in dbSNP:rs2295182) /FTId=VAR_020466 VARIANT 600 600 P -> R (in dbSNP:rs11557577) /FTId=VAR_033839 VARIANT 738 738 A -> S (in dbSNP:rs6081027) /FTId=VAR_048166 CONFLICT 535 535 R -> G (in Ref. 1; BAB14669) SEQUENCE 782 AA; 88844 MW; E84FAEF06412EA77 CRC64; MDSSIHLSSL ISRHDDEATR TSTSEGLEEG EVEGETLLIV ESEDQASVDL SHDQSGDSLN SDEGDVSWME EQLSYFCDKC QKWIPASQLR EQLSYLKGDN FFRFTCSDCS ADGKEQYERL KLTWQQVVML AMYNLSLEGS GRQGYFRWKE DICAFIEKHW TFLLGNRKKT STWWSTVAGC LSVGSPMYFR SGAQEFGEPG WWKLVHNKPP TMKPEGEKLS ASTLKIKAAS KPTLDPIITV EGLRKRASRN PVESAMELKE KRSRTQEAKD IRRAQKEAAG FLDRSTSSTP VKFISRGRRP DVILEKGEVI DFSSLSSSDR TPLTSPSPSP SLDFSAPGTP ASHSATPSLL SEADLIPDVM PPQALFHDDD EMEGDGVIDP GMEYVPPPAG SVASGPVVGV RKKVRGPEQI KQEVESEEEK PDRMDIDSED TDSNTSLQTR AREKRKPQLE KDTKPKEPRY TPVSIYEEKL LLKRLEACPG AVAMTPEARR LKRKLIVRQA KRDRGLPLFD LDQVVNAALL LVDGIYGAKE GGISRLPAGQ ATYRTTCQDF RILDRYQTSL PSRKGFRHQT TKFLYRLVGS EDMAVDQSIV SPYTSRILKP YIRRDYETKP PKLQLLSQIR SHLHRSDPHW TPEPDAPLDY CYVRPNHIPT INSMCQEFFW PGIDLSECLQ YPDFSVVVLY KKVIIAFGFM VPDVKYNEAY ISFLFVHPEW RRAGIATFMI YHLIQTCMGK DVTLHVSASN PAMLLYQKFG FKTEEYVLDF YDKYYPLEST ECKHAFFLRL RR
Citations (0)

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Background

CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Two transcript variants encoding different isoforms have been found for this gene.

References

Venkatesan,K.,et.al., Nat. Methods 6 (1), 83-90 (2009)

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Cat# AP8865c
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