|Application ||WB, E|
|Calculated MW||129295 Da|
|Antigen Region||1023-1049 aa|
|Other Names||Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, GPIa, VLA-2 subunit alpha, CD49b, ITGA2, CD49B|
|Target/Specificity||This ITGA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1023-1049 amino acids from the C-terminal region of human ITGA2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ITGA2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
ITGA2 id a protein that belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
Ye,F., Hu,G., et.al., J. Cell Biol. 188 (1), 157-173 (2010)
Jokinen,J., et.al., EMBO J. 29 (1), 196-208 (2010)
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