|Application ||WB, IHC-P, FC, E|
|Calculated MW||43179 Da|
|Antigen Region||337-364 aa|
|Other Names||Fibromodulin, FM, Collagen-binding 59 kDa protein, Keratan sulfate proteoglycan fibromodulin, KSPG fibromodulin, FMOD, FM, SLRR2E|
|Target/Specificity||This FMOD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 337-364 amino acids from the C-terminal region of human FMOD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FMOD Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
Fibromodulin is a member of a family of small interstitial proteoglycans, containing a central region composed of leucine-rich repeats with 4 keratan sulfate chains flanked by disulfide-bonded terminal domains. It may participate in the assembly of the extracellular matrix as it interacts with type I and type II collagen fibrils and inhibits fibrillogenesis in vitro. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix.
Ehret,G.B., et.al, Eur. J. Hum. Genet. 17 (12), 1650-1657 (2009)
Tillgren,V., et.al, J. Biol. Chem. 284 (42), 28543-28553 (2009)
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