|Application ||IHC-P, WB, E|
|Calculated MW||68297 Da|
|Antigen Region||539-568 aa|
|Other Names||Actin-related protein 5, hARP5, Sarcoma antigen NY-SAR-16, ACTR5, ARP5|
|Target/Specificity||This ACTR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 539-568 amino acids from the C-terminal region of human ACTR5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACTR5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.|
|Cellular Location||Nucleus Cytoplasm. Note=Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling (PubMed:19014934). Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses (PubMed:18163988)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ACTR5 may be involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex
Kitayama,K., et.al., Exp. Cell Res. 315 (2), 206-217 (2009)
Jin,J., et.al., J. Biol. Chem. 280 (50), 41207-41212 (2005)
Lee,S.Y., et.al., Proc. Natl. Acad. Sci. U.S.A. 100 (5), 2651-2656 (2003)
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