- CITATIONS: 1
|Application ||IHC-P, FC, E|
|Calculated MW||47584 Da|
|Antigen Region||249-277 aa|
|Other Names||B-cell lymphoma 3 protein, BCL-3, Proto-oncogene BCL3, BCL3, BCL4, D19S37|
|Target/Specificity||This BCL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-277 amino acids from the Central region of human BCL3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BCL3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Ubiquitination via 'Lys- 63'-linked ubiquitin chains is required for nuclear accumulation|
Provided below are standard protocols that you may find useful for product applications.
BCL3 is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers.
Kabuta,T. et.al., Biochem. Biophys. Res. Commun. 394 (3), 697-702 (2010)
Talmud,P.J. et.al., Am. J. Hum. Genet. 85 (5), 628-642 (2009)
Folco,E.J. et.al., J. Biol. Chem. 284 (38), 25569-25575 (2009)
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