|Application ||FC, IHC-P, WB, E|
|Calculated MW||116598 Da|
|Antigen Region||822-849 aa|
|Other Names||Hormone-sensitive lipase, HSL, LIPE|
|Target/Specificity||This LIPE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 822-849 amino acids from the C-terminal region of human LIPE.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LIPE Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.|
|Cellular Location||Cell membrane. Membrane, caveola. Cytoplasm, cytosol. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation|
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Provided below are standard protocols that you may find useful for product applications.
LIPE has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids.
Bezaire, V., et al. FEBS Lett. 583(18):3045-3049(2009)
Chen, H.H., et al. Am. J. Clin. Nutr. 90(2):255-262(2009)
Kuzmin, A., et al. Biol. Reprod. 81(2):319-326(2009)
Bezaire, V., et al. J. Biol. Chem. 284(27):18282-18291(2009)
Drenos, F., et al. Hum. Mol. Genet. 18(12):2305-2316(2009)
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