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BTBD10 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - BTBD10 Antibody (Center) AP9476c
    Western blot analysis of BTBD10 Antibody (Center) (Cat. #AP9476c) in K562 cell line lysates (35ug/lane). BTBD10 (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BSF8
Other Accession Q80X66
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 191-218 aa
Additional Information
Other Names BTB/POZ domain-containing protein 10, Glucose metabolism-related protein 1, BTBD10, GMRP1 {ECO:0000303|PubMed:21267538}
Target/Specificity This BTBD10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-218 amino acids from the Central region of human BTBD10.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBTBD10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BTBD10
Synonyms GMRP1 {ECO:0000303|PubMed:21267538}
Function Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.
Cellular Location Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q80X66}. Note=Colocalizes with KCTD20 in filamentous structures. {ECO:0000250|UniProtKB:Q80X66}
Tissue Location Ubiquitously expressed. Highly expressed in adult brain, testis, aorta and small intestine and weakly expressed in the heart, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary and colon. Down-regulated in glioma EMBL; AY221959; AAO64360.1; -; mRNA EMBL; AK294259; BAH11714.1; -; mRNA EMBL; AK316163; BAH14534.1; -; mRNA EMBL; AL832981; CAH56329.1; -; mRNA EMBL; AC016884; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC021269; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC005071; AAH05071.2; -; mRNA CCDS; CCDS73261.1; -. [Q9BSF8-2] CCDS; CCDS7811.1; -. [Q9BSF8-1] RefSeq; NP_001284671.1; NM_001297742.1. [Q9BSF8-2] RefSeq; NP_115696.2; NM_032320.6. [Q9BSF8-1] RefSeq; XP_016873897.1; XM_017018408.1 UniGene; Hs.332382; - ProteinModelPortal; Q9BSF8; - BioGrid; 124007; 12 IntAct; Q9BSF8; 9 MINT; Q9BSF8; - STRING; 9606.ENSP00000278174; - iPTMnet; Q9BSF8; - PhosphoSitePlus; Q9BSF8; - BioMuta; BTBD10; - DMDM; 74733002; - EPD; Q9BSF8; - jPOST; Q9BSF8; - MaxQB; Q9BSF8; - PaxDb; Q9BSF8; - PeptideAtlas; Q9BSF8; - PRIDE; Q9BSF8; - ProteomicsDB; 78886; - DNASU; 84280; - Ensembl; ENST00000278174; ENSP00000278174; ENSG00000148925. [Q9BSF8-1] Ensembl; ENST00000530907; ENSP00000431186; ENSG00000148925. [Q9BSF8-2] GeneID; 84280; - KEGG; hsa:84280; - UCSC; uc001mkz.4; human. [Q9BSF8-1] CTD; 84280; - DisGeNET; 84280; - EuPathDB; HostDB:ENSG00000148925.10; - GeneCards; BTBD10; - HGNC; HGNC:21445; BTBD10 HPA; HPA046777; - MIM; 615933; gene neXtProt; NX_Q9BSF8; - OpenTargets; ENSG00000148925; - PharmGKB; PA142672543; - eggNOG; KOG3840; Eukaryota eggNOG; ENOG410XSS5; LUCA GeneTree; ENSGT00390000007975; - HOGENOM; HOG000261659; - HOVERGEN; HBG059410; - InParanoid; Q9BSF8; - KO; K10482; - OMA; RKQFEFY; - OrthoDB; 390051at2759; - PhylomeDB; Q9BSF8; - TreeFam; TF314369; - ChiTaRS; BTBD10; human GenomeRNAi; 84280; - PRO; PR:Q9BSF8; - Proteomes; UP000005640; Chromosome 11 Bgee; ENSG00000148925; Expressed in 205 organ(s), highest expression level in corpus callosum ExpressionAtlas; Q9BSF8; baseline and differential Genevisible; Q9BSF8; HS GO; GO:0005737; C:cytoplasm; ISS:UniProtKB GO; GO:0001650; C:fibrillar center; IDA:HPA GO; GO:0005634; C:nucleus; IDA:HPA GO; GO:1901215; P:negative regulation of neuron death; ISS:UniProtKB GO; GO:0042327; P:positive regulation of phosphorylation; ISS:UniProtKB GO; GO:0044342; P:type B pancreatic cell proliferation; ISS:UniProtKB InterPro; IPR000210; BTB/POZ_dom InterPro; IPR039886; BTBD10/KCTD20 InterPro; IPR039885; BTBD10/KCTD20_BTB/POZ InterPro; IPR011333; SKP1/BTB/POZ_sf PANTHER; PTHR21637; PTHR21637; 1 Pfam; PF16017; BTB_3; 1 SMART; SM00225; BTB; 1 SUPFAM; SSF54695; SSF54695; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome CHAIN 1 475 BTB/POZ domain-containing protein 10 /FTId=PRO_0000228985 DOMAIN 167 241 BTB REGION 146 475 Interaction with AKT family members {ECO:0000250|UniProtKB:Q80X66} COMPBIAS 106 142 Ser-rich VAR_SEQ 1 33 MAGRPHPYDGNSSDPENWDRKLHSRPRKLYKHS -> MPKD ADLAFSASLFERAESLYTLISKFFSCFCVSTLAYTKG (in isoform 2) /FTId=VSP_055552 VARIANT 145 145 T -> A (in dbSNP:rs34185489) /FTId=VAR_033638 SEQUENCE 475 AA; 53779 MW; 0D6433891EAA33A6 CRC64; MAGRPHPYDG NSSDPENWDR KLHSRPRKLY KHSSTSSRIA KGGVDHTKMS LHGASGGHER SRDRRRSSDR SRDSSHERTE SQLTPCIRNV TSPTRQHHVE REKDHSSSRP SSPRPQKASP NGSISSAGNS SRNSSQSSSD GSCKTAGEMV FVYENAKEGA RNIRTSERVT LIVDNTRFVV DPSIFTAQPN TMLGRMFGSG REHNFTRPNE KGEYEVAEGI GSTVFRAILD YYKTGIIRCP DGISIPELRE ACDYLCISFE YSTIKCRDLS ALMHELSNDG ARRQFEFYLE EMILPLMVAS AQSGERECHI VVLTDDDVVD WDEEYPPQMG EEYSQIIYST KLYRFFKYIE NRDVAKSVLK ERGLKKIRLG IEGYPTYKEK VKKRPGGRPE VIYNYVQRPF IRMSWEKEEG KSRHVDFQCV KSKSITNLAA AAADIPQDQL VVMHPTPQVD ELDILPIHPP SGNSDLDPDA QNPML
Research Areas
Citations (0)

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BTBD10 appears to behave as a suppressor of cell death, which includes neuronal cell death related to amyotrophic lateral sclerosis. It may also act as an enhancer of cell growth via its positive regulation of Akt phosphorylation.


?Nawa, M., et al. Cell. Signal. 20(3):493-505(2008)
?Chen, J., et al. Gene 340(1):61-69(2004)

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$ 325.00
$ 109.00
Cat# AP9476c
Availability: In Stock
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