|Application ||WB, E|
|Calculated MW||214760 Da|
|Antigen Region||343-371 aa|
|Other Names||Receptor-type tyrosine-protein phosphatase delta, Protein-tyrosine phosphatase delta, R-PTP-delta, PTPRD|
|Target/Specificity||This PTPRD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-371 amino acids from the N-terminal region of human PTPRD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTPRD Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
PTPRD is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance.
?Wallace, M.J., et al. Mol. Cell. Biol. 18(5):2608-2616(1998)
?Pulido, R., et al. Proc. Natl. Acad. Sci. U.S.A. 92(25):11686-11690(1995)
?Pulido, R., et al. J. Biol. Chem. 270(12):6722-6728(1995)
?Krueger, N.X., et al. EMBO J. 9(10):3241-3252(1990)
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