|Application ||WB, E|
|Calculated MW||21008 Da|
|Antigen Region||139-168 aa|
|Other Names||Gamma-glutamylcyclotransferase, Cytochrome c-releasing factor 21, GGCT, C7orf24, CRF21|
|Target/Specificity||This GGCT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 139-168 amino acids from the C-terminal region of human GGCT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GGCT Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.|
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Provided below are standard protocols that you may find useful for product applications.
GGCT (EC 220.127.116.11) catalyzes the formation of 5-oxoproline (pyroglutamic acid) from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis.
Oakley, A.J., et al. J. Biol. Chem. 283(32):22031-22042(2008)
Bae, E., et al. Proteins 70(2):588-591(2008)
Masuda, Y., et al. Biochem. Biophys. Res. Commun. 346(2):454-460(2006)
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