|Application ||WB, E|
|Calculated MW||46189 Da|
|Antigen Region||353-382 aa|
|Other Names||Protein O-glucosyltransferase 1, 241-, CAP10-like 46 kDa protein, hCLP46, KTEL motif-containing protein 1, Myelodysplastic syndromes relative protein, O-glucosyltransferase Rumi homolog, hRumi, Protein O-xylosyltransferase, POGLUT1, C3orf9, CLP46, KTELC1, MDSRP|
|Target/Specificity||This KTEL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-382 amino acids from the C-terminal region of human KTEL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KTEL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (PubMed:27807076). Notch glucosylation does not affect Notch ligand binding (PubMed:21490058). Required during early development to promote gastrulation: acts by mediating O- glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity).|
|Cellular Location||Endoplasmic reticulum lumen|
|Tissue Location||Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. Expressed in the epidermis, especially in the upper parts, stratum spinosum and stratum granulosum (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Karadonta, A.V., et al. Int J Immunopathol Pharmacol 22(3):787-793(2009)
Teng, Y., et al. Gene 371(1):7-15(2006)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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