- CITATIONS: 1
|Application ||IHC-P, E|
|Calculated MW||99147 Da|
|Antigen Region||271-300 aa|
|Other Names||Cone cGMP-specific 3', 5'-cyclic phosphodiesterase subunit alpha', cGMP phosphodiesterase 6C, PDE6C, PDEA2|
|Target/Specificity||This PDE6C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-300 amino acids from the Central region of human PDE6C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDE6C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side|
Provided below are standard protocols that you may find useful for product applications.
PDE6C is the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa.
Muradov, H., et al. J. Biol. Chem. 284(47):32662-32669(2009) Chang, B., et al. Proc. Natl. Acad. Sci. U.S.A. 106(46):19581-19586(2009) Thiadens, A.A., et al. Am. J. Hum. Genet. 85(2):240-247(2009)
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