|Application ||WB, IHC-P, FC, E|
|Calculated MW||94254 Da|
|Antigen Region||603-632 aa|
|Other Names||Calpain-3, Calcium-activated neutral proteinase 3, CANP 3, Calpain L3, Calpain p94, Muscle-specific calcium-activated neutral protease 3, New calpain 1, nCL-1, CAPN3, CANP3, CANPL3, NCL1|
|Target/Specificity||This CAPN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-632 amino acids from the C-terminal region of human CAPN3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CAPN3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CANP3, CANPL3, NCL1|
|Function||Calcium-regulated non-lysosomal thiol-protease.|
|Tissue Location||Isoform I is skeletal muscle specific.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A.
Charlton, R., et al. Neuromuscul. Disord. 19(7):449-457(2009)
Moretti, D., et al. Carcinogenesis 30(6):960-967(2009)
Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008)
Beckmann, J.S., et al. Neuromuscul. Disord. 18(12):913-921(2008)
Shirafuji, T., et al. Rinsho Shinkeigaku 48(9):651-655(2008)
Diaz, B.G., et al. J. Biol. Chem. 279(26):27656-27666(2004)
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