|Application ||WB, E|
|Antigen Region||56-82 aa|
|Other Names||CD160 antigen, Natural killer cell receptor BY55, CD160, CD160, BY55|
|Target/Specificity||This CD160 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-82 amino acids from the Central region of human CD160.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD160 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor showing broad specificity for both classical and non-classical MHC class I molecules.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor.|
|Tissue Location||Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to functional NK and T cytotoxic lymphocytes EMBL; AF060981; AAC72302.1; -; mRNA EMBL; BC014465; AAH14465.1; -; mRNA CCDS; CCDS72861.1; - RefSeq; NP_008984.1; NM_007053.3 UniGene; Hs.488237; - UniGene; Hs.740780; - ProteinModelPortal; O95971; - SMR; O95971; - BioGrid; 116299; 41 IntAct; O95971; 9 MINT; O95971; - STRING; 9606.ENSP00000235933; - iPTMnet; O95971; - PhosphoSitePlus; O95971; - BioMuta; CD160; - EPD; O95971; - PaxDb; O95971; - PeptideAtlas; O95971; - PRIDE; O95971; - ProteomicsDB; 51154; - DNASU; 11126; - Ensembl; ENST00000235933; ENSP00000235933; ENSG00000117281 Ensembl; ENST00000369288; ENSP00000358294; ENSG00000117281 GeneID; 11126; - KEGG; hsa:11126; - CTD; 11126; - DisGeNET; 11126; - EuPathDB; HostDB:ENSG00000117281.15; - GeneCards; CD160; - HGNC; HGNC:17013; CD160 MIM; 604463; gene neXtProt; NX_O95971; - OpenTargets; ENSG00000117281; - PharmGKB; PA134943137; - eggNOG; ENOG410IX7D; Eukaryota eggNOG; ENOG411156J; LUCA GeneTree; ENSGT00390000007258; - HOVERGEN; HBG018849; - InParanoid; O95971; - KO; K06542; - PhylomeDB; O95971; - TreeFam; TF338321; - Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell GeneWiki; CD160; - GenomeRNAi; 11126; - PRO; PR:O95971; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000117281; - CleanEx; HS_CD160; - ExpressionAtlas; O95971; baseline and differential Genevisible; O95971; HS GO; GO:0046658; C:anchored component of plasma membrane; IDA:HGNC GO; GO:0005886; C:plasma membrane; TAS:Reactome GO; GO:0032393; F:MHC class I receptor activity; IDA:HGNC GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc GO; GO:0005102; F:signaling receptor binding; IDA:HGNC GO; GO:0008283; P:cell proliferation; TAS:ProtInc GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc GO; GO:0006968; P:cellular defense response; TAS:ProtInc GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl GO; GO:0050776; P:regulation of immune response; TAS:Reactome Gene3D; 22.214.171.124; -; 1 InterPro; IPR036179; Ig-like_dom_sf InterPro; IPR013783; Ig-like_fold SUPFAM; SSF48726; SSF48726; 1 1: Evidence at protein level; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain; Lipoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Signal SIGNAL 1 26 CHAIN 27 159 CD160 antigen /FTId=PRO_0000014543 PROPEP 160 181 Removed in mature form. /FTId=PRO_0000014544 DOMAIN 27 122 Ig-like V-type LIPID 159 159 GPI-anchor amidated serine CARBOHYD 28 28 N-linked (GlcNAc...) asparagine CARBOHYD 137 137 N-linked (GlcNAc...) asparagine DISULFID 44 112 DISULFID 61 68 VARIANT 91 91 I -> V (in dbSNP:rs2231373) /FTId=VAR_027747 SEQUENCE 181 AA; 19810 MW; EF0B981ACC7478BD CRC64; MLLEPGRGCC ALAILLAIVD IQSGGCINIT SSASQEGTRL NLICTVWHKK EEAEGFVVFL CKDRSGDCSP ETSLKQLRLK RDPGIDGVGE ISSQLMFTIS QVTPLHSGTY QCCARSQKSG IRLQGHFFSI LFTETGNYTV TGLKQRQHLE FSHNEGTLSS GFLQEKVWVM LVTSLVALQA L|
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Provided below are standard protocols that you may find useful for product applications.
CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.
Schmitt, C., et al. Genes Immun. 10(7):616-623(2009)
Kolz, M., et al. PLoS Genet. 5 (6), E1000504 (2009)
Giustiniani, J., et al. J. Immunol. 182(1):63-71(2009)
Cai, G., et al. Nat. Immunol. 9(2):176-185(2008)
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