|Application ||WB, IHC-P, FC, E|
|Calculated MW||76645 Da|
|Antigen Region||690-717 aa|
|Other Names||G2 and S phase-expressed protein 1, GTSE-1, Protein B99 homolog, GTSE1|
|Target/Specificity||This GTSE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 690-717 amino acids from the C-terminal region of human GTSE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GTSE1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.|
|Cellular Location||Cytoplasm, cytoskeleton. Note=Associated with microtubules|
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Provided below are standard protocols that you may find useful for product applications.
GTSE1 is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.
Bublik, D.R., et al. J. Biol. Chem. 285(8):5274-5281(2010)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Kapranov, P., et al. Genome Res. 15(7):987-997(2005)
Cheng, J., et al. Science 308(5725):1149-1154(2005)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
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