|Application ||WB, FC, E|
|Calculated MW||67723 Da|
|Antigen Region||261-290 aa|
|Other Names||mRNA-decapping enzyme 1B, 3---, DCP1B|
|Target/Specificity||This DCP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-290 amino acids of human DCP1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DCP1B Antibody (center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay.
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
Cougot, N., et al. J. Cell Biol. 165(1):31-40(2004)
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