|Application ||WB, IHC-P, FC, E|
|Calculated MW||31874 Da|
|Antigen Region||265-291 aa|
|Other Names||RPE-retinal G protein-coupled receptor, RGR|
|Target/Specificity||This RGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-291 amino acids from the Central region of human RGR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RGR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Preferentially expressed at high levels in the retinal pigment epithelium (RPE) and Mueller cells of the neural retina|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively).
Kochounian, H., et al. Exp. Eye Res. 88(6):1129-1136(2009)
Radu, R.A., et al. J. Biol. Chem. 283(28):19730-19738(2008)
Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)
Lin, M.Y., et al. Mol. Vis. 13, 1203-1214 (2007)
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