|Application ||WB, IHC-P, E|
|Calculated MW||56572 Da|
|Antigen Region||1-30 aa|
|Other Names||Autophagy-related protein 13, ATG13, KIAA0652|
|Target/Specificity||This ATG13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ATG13.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATG13 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|
|Cellular Location||Cytoplasm, cytosol. Preautophagosomal structure. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation|
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Provided below are standard protocols that you may find useful for product applications.
Hosokawa, N., et al. Autophagy 5(7):973-979(2009) Mercer, C.A., et al. Autophagy 5(5):649-662(2009) Ganley, I.G., et al. J. Biol. Chem. 284(18):12297-12305(2009) Jung, C.H., et al. Mol. Biol. Cell 20(7):1992-2003(2009) Hosokawa, N., et al. Mol. Biol. Cell 20(7):1981-1991(2009)
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