Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.PLATELET-DERIVED GROWTH FACTOR B CHAIN (PDGF-B) Affinity Purified Antibody
Purified Sheep Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E, DB |
|---|---|
| Host | Sheep |
| Clonality | Polyclonal |
| Other Names | Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide; PDGF-1; PDGF subunit A; PDGFA; PDGF1; Platelet-derived growth factor subunit A |
|---|---|
| Reconstitution & Storage | Store at -20°C. Avoid freeze / thaw cycles. Short term storage +2°C-+8°C |
| Precautions | PLATELET-DERIVED GROWTH FACTOR B CHAIN (PDGF-B) Affinity Purified Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The term PDGF refers to a family of disulphide bondlinked dimeric isoforms that act as autocrine and paracrine growth factors and are produced by a variety of cell types other than platelets. They act as potent mitogens for almost all mesenchymally-derived cells. Aberrant expression is involved in certain cancers, fibroproliferative disorders and atherosclerosis. The protein also contributes to wound healing and neural regeneration. There are four members of the PDGF family PDGF A, PDGF B, PDGF C and PDGF D. Two distinct types of PDGF-A exist a short form that is soluble and a long form that is retained by the extracellular matrix. RANDOX recombinant PDGF-A comprises a 110 amino acid fragment (87-196) corresponding to the mature PDGF-A short chain protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use
References
Raines, E.W. & Ross, R. (1982) J. Biol. Chem. 257(9) : 5154-5160. Bonthron, D.T. et al. (1988). Proc. Natl. Acad. Sci USA 85(5): 1492-1496.
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