|Application ||WB, IF, E|
|Other Accession||NP_001036013, 110349756|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||39666 Da|
|Application Notes||FEZ2 antibody can be used for the detection of FEZ2 by Western blot at 0.5 - 1 µg/mL. Antibody can also be used for immunoflourescence starting at 5 µg/mL. For immunofluorescence start at 5 µg/mL.|
|Reconstitution & Storage||FEZ2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||FEZ2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in axonal outgrowth and fasciculation.|
|Tissue Location||Expressed in nonneural tissues, such as heart, lung, spleen, muscle, testis, placenta and melanocytes|
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Provided below are standard protocols that you may find useful for product applications.
FEZ2 Antibody: Fasciculation and elongation protein zeta-2 (FEZ2) is a homolog to the mammalian FEZ1, itself an ortholog of the C. elegans UNC-76. In contrast to FEZ1, FEZ2 mRNA is widely expressed in mouse tissues. FEZ2 interacts with protein kinase C (PKC)-zeta substrate and induces neurite extension of PC12 cells when co-expressed with a constitutively active form of PKC-zeta, suggesting FEZ2 may play an important role in the morphological changes of various cells by associating with PKC-zeta in a tissue non-specific manner. FEZ2 can interact with FEZ1 through its c-terminal regions and especially its coiled-coil region. At least two isoforms of FEZ2 are known to exist.
Fujita T, Ikuta J, Okajima T, et al. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. Biochem. Biophys. Res. Commun.2004; 313:738-44.
Kuroda S, Nakagawa N, Tokunaga C, et al. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C z-interacting protein. J. Cell Biol.1999; 144:403-11.
Assmann EM, Alborghetti MR, Camargo MER, et al. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. J. Biol. Chem.2006; 281:9869-81.
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