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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   ZBED3 Antibody   

ZBED3 Antibody

  • WB - ZBED3 Antibody ASC10885
    Western blot analysis of ZBED3 in A20 cell lysate with ZBED3 antibody at 1 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96IU2
Other Accession NP_115743, 14150185
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Application Notes ZBED3 antibody can be used for detection of ZBED3 by Western blot at 1 - 2 µg/mL. Despite its predicted molecular weight, ZBED3 often migrates at a higher position in SDS-PAGE.
Additional Information
Gene ID 84327
Target/Specificity ZBED3; This antibody is predicted to have no cross-reactivity to ZBED1 or ZBED2.
Reconstitution & Storage ZBED3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsZBED3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZBED3
Function Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity).
Cellular Location Cytoplasm. Membrane. Note=Colocalizes with AXIN1 in the cytoplasm EMBL; AC008581; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC007239; AAH07239.1; -; mRNA CCDS; CCDS4036.1; - RefSeq; NP_001316493.1; NM_001329564.1 RefSeq; NP_115743.1; NM_032367.3 UniGene; Hs.584988; - ProteinModelPortal; Q96IU2; - SMR; Q96IU2; - BioGrid; 124051; 3 IntAct; Q96IU2; 1 iPTMnet; Q96IU2; - PhosphoSitePlus; Q96IU2; - DMDM; 34925646; - MaxQB; Q96IU2; - PaxDb; Q96IU2; - PeptideAtlas; Q96IU2; - PRIDE; Q96IU2; - ProteomicsDB; 76853; - Ensembl; ENST00000255198; ENSP00000255198; ENSG00000132846 GeneID; 84327; - KEGG; hsa:84327; - UCSC; uc003kev.2; human CTD; 84327; - EuPathDB; HostDB:ENSG00000132846.5; - GeneCards; ZBED3; - HGNC; HGNC:20711; ZBED3 HPA; HPA055995; - MIM; 615250; gene neXtProt; NX_Q96IU2; - OpenTargets; ENSG00000132846; - PharmGKB; PA134974972; - eggNOG; ENOG410IXJY; Eukaryota eggNOG; ENOG41115R7; LUCA GeneTree; ENSGT00390000013530; - HOGENOM; HOG000136530; - InParanoid; Q96IU2; - OMA; AAPEGDW; - OrthoDB; EOG091G0JGE; - PhylomeDB; Q96IU2; - TreeFam; TF338048; - ChiTaRS; ZBED3; human GenomeRNAi; 84327; - PRO; PR:Q96IU2; - Proteomes; UP000005640; Chromosome 5 Bgee; ENSG00000132846; - CleanEx; HS_ZBED3; - ExpressionAtlas; Q96IU2; baseline and differential Genevisible; Q96IU2; HS GO; GO:0005829; C:cytosol; ISS:UniProtKB GO; GO:0016020; C:membrane; ISS:UniProtKB GO; GO:0003677; F:DNA binding; IEA:InterPro GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0001933; P:negative regulation of protein phosphorylation; ISS:UniProtKB GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISS:UniProtKB GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB GO; GO:0050821; P:protein stabilization; ISS:UniProtKB GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW InterPro; IPR033546; ZBED3 InterPro; IPR003656; Znf_BED InterPro; IPR036236; Znf_C2H2_sf PANTHER; PTHR35827:SF2; PTHR35827:SF2; 1 Pfam; PF02892; zf-BED; 1 SMART; SM00614; ZnF_BED; 1 SUPFAM; SSF57667; SSF57667; 1 PROSITE; PS50808; ZF_BED; 1 1: Evidence at protein level; Complete proteome; Cytoplasm; Membrane; Metal-binding; Reference proteome; Wnt signaling pathway; Zinc; Zinc-finger CHAIN 1 234 Zinc finger BED domain-containing protein 3 /FTId=PRO_0000066562 ZN_FING 43 104 BED-type. {ECO:0000255|PROSITE- ProRule:PRU00027} COMPBIAS 142 202 Arg-rich SEQUENCE 234 AA; 25132 MW; 3E615F16B68EE3B2 CRC64; MRSGEPACTM DQARGLDDAA ARGGQCPGLG PAPTPTPPGR LGAPYSEAWG YFHLAPGRPG HPSGHWATCR LCGEQVGRGP GFHAGTSALW RHLRSAHRRE LESSGAGSSP PAAPCPPPPG PAAAPEGDWA RLLEQMGALA VRGSRREREL ERRELAVEQG ERALERRRRA LQEEERAAAQ ARRELQAERE ALQARLRDVS RREGALGWAP AAPPPLKDDP EGDRDGCVIT KVLL
Research Areas
Citations (0)

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ZBED3 Antibody: Axin is a key modulator of the Wnt/beta-catenin pathway and acts as a scaffold protein in phosphorylating and degrading cytoplasmic beta-catenin. ZBED3, a member of the Zinc finger BED-type domain containing superfamily, has been recently identified as an Axin-interacting protein and has been suggested to modulate the Wnt/beta-catenin signaling pathway. RNA interference (RNAi) experiments targeting ZBED3 RNA attenuated Wnt-induced beta-catenin accumulation, lymphoid enhancer binding factor-1-dependent luciferase reporter activity, and Wnt gene expression.


Chen T, Li M, Ding Y, et al. Identification of Zinc-finger BED domain containing 3 (Zbed3) as a novel axin-interacting protein that activates Wnt/b-catenin signaling. J. Biol. Chem.2009; 284:6683-9.

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$ 335.00
Cat# ASC10885
Availability: 5-7days
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