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Prosapip2 Antibody

  • WB - Prosapip2 Antibody ASC10980
    Western blot analysis of Prosapip2 in rat liver tissue lysate with Prosapip2 antibody at 1 µg/mL.
  • IHC - Prosapip2 Antibody ASC10980
    Immunohistochemistry of Prosapip2 in rat liver tissue with Prosapip2 antibody at 5 µg/mL.
  • IF - Prosapip2 Antibody ASC10980
    Immunofluorescence of Prosapip 2 in rat liver tissue with Prosapip 2 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession A7MCY6
Other Accession NP_055541, 7662302
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 67702 Da
Application Notes Prosapip2 antibody can be used for detection of Prosapip2 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 9755
Target/Specificity TBKBP1;
Reconstitution & Storage Prosapip2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsProsapip2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TBKBP1 {ECO:0000312|EMBL:AAI11419.1}
Function Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.
Tissue Location Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus.
Research Areas
Citations (0)

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Prosapip2 Antibody: Prosapip2 (TBKBP1) is essential for signal transduction during viral infection thus plays a major role in the TNF/NF-κB pathway. It is an adaptor protein that constitutively binds TBK1 (TANK-binding kinase) and IKBKE and may play a role in antiviral innate immunity. Prosapip2 is a 615 amino acid adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It has a ubiquitous expression with highest levels in ovary, followed by the neuronal system. Prosapip2 binds to TBK1 and helps in the activation of IRF3 which controls the expression of antiviral genes during infection. Recent studies show that Prosapip2 is an interaction partner of ProSAP2/Shank3 and actin, suggesting a role as a linker molecule between postsynaptic density and the cytoskeleton.


Bouwmeester T, Bauch A, Ruffner H, et al. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat. Cell Biol.2004; 6:97-105
Ryzhakov G and Randow F. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. EMBO J.2007; 26:3180-90.
Meffert MK, Chang JM, Wiltgen BJ, et al. NF-kappa B functions in synaptic signaling and behavior. Nat. Neurosci.2003; 6:1072-78.
Liebau S, Proepper C, Schmidt T, et al. ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3. Biochem. Biophys. Res Commun.2009; 385:460-5.

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$ 335.00
Cat# ASC10980
Availability: 5-7days
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