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BCAS1 Antibody

  • WB - BCAS1 Antibody ASC11075
    Western blot analysis of BCAS1 in human lung tissue lysate with BCAS1 antibody at 1 µg/mL.
  • IHC - BCAS1 Antibody ASC11075
    Immunohistochemistry of BCAS1 in human breast carcinoma with BCAS1 antibody at 5 µg/mL.
  • IF - BCAS1 Antibody ASC11075
    Immunofluorescence of BCAS1 in Human Breast Carcinoma cells with BCAS1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75363
Other Accession EAW75575, 119595981
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Application Notes BCAS1 antibody can be used for detection of BCAS1 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 8537
Target/Specificity BCAS1;
Reconstitution & Storage BCAS1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsBCAS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCAS1
Synonyms AIBC1, NABC1
Cellular Location Cytoplasm.
Tissue Location Expressed in brain and prostate, and at lower levels in testis, intestine and colon. Overexpressed in most breast cancer cell lines and down-regulated in some colorectal tumors. EMBL; AF041260; AAC39896.1; -; mRNA EMBL; AC004501; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC005220; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC126346; AAI26347.1; -; mRNA EMBL; AI904532; -; NOT_ANNOTATED_CDS; mRNA EMBL; CR749643; CAH18437.1; -; mRNA CCDS; CCDS13444.1; -. [O75363-1] RefSeq; NP_003648.2; NM_003657.3. [O75363-1] UniGene; Hs.400556; - ProteinModelPortal; O75363; - SMR; O75363; - BioGrid; 114107; 3 IntAct; O75363; 2 STRING; 9606.ENSP00000379290; - iPTMnet; O75363; - PhosphoSitePlus; O75363; - BioMuta; BCAS1; - MaxQB; O75363; - PaxDb; O75363; - PeptideAtlas; O75363; - PRIDE; O75363; - ProteomicsDB; 49926; - ProteomicsDB; 49927; -. [O75363-2] DNASU; 8537; - Ensembl; ENST00000395961; ENSP00000379290; ENSG00000064787. [O75363-1] GeneID; 8537; - KEGG; hsa:8537; - UCSC; uc002xws.3; human. [O75363-1] CTD; 8537; - DisGeNET; 8537; - EuPathDB; HostDB:ENSG00000064787.12; - GeneCards; BCAS1; - H-InvDB; HIX0015925; - HGNC; HGNC:974; BCAS1 HPA; CAB033558; - HPA; HPA051816; - HPA; HPA054745; - MIM; 602968; gene neXtProt; NX_O75363; - OpenTargets; ENSG00000064787; - PharmGKB; PA25284; - eggNOG; ENOG410IJ5W; Eukaryota eggNOG; ENOG41119UT; LUCA GeneTree; ENSGT00390000003167; - HOGENOM; HOG000232037; - HOVERGEN; HBG082347; - InParanoid; O75363; - OMA; PQRVEDQ; - OrthoDB; EOG091G07RJ; - PhylomeDB; O75363; - TreeFam; TF335555; - ChiTaRS; BCAS1; human GeneWiki; BCAS1; - GenomeRNAi; 8537; - PRO; PR:O75363; - Proteomes; UP000005640; Chromosome 20 Bgee; ENSG00000064787; - CleanEx; HS_BCAS1; - ExpressionAtlas; O75363; baseline and differential Genevisible; O75363; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB InterPro; IPR026115; NABC1 PANTHER; PTHR15016; PTHR15016; 2 1: Evidence at protein level; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome CHAIN 1 584 Breast carcinoma-amplified sequence 1 /FTId=PRO_0000064859 MOD_RES 124 124 Phosphoserine {ECO:0000250|UniProtKB:Q3ZB98} MOD_RES 192 192 Phosphoserine {ECO:0000250|UniProtKB:Q3ZB98} MOD_RES 314 314 Phosphoserine {ECO:0000250|UniProtKB:Q3ZB98} MOD_RES 381 381 Phosphoserine {ECO:0000250|UniProtKB:Q80YN3} MOD_RES 399 399 Phosphoserine {ECO:0000250|UniProtKB:Q80YN3} MOD_RES 480 480 Phosphothreonine {ECO:0000250|UniProtKB:Q80YN3} MOD_RES 552 552 Phosphoserine {ECO:0000250|UniProtKB:Q3ZB98} VAR_SEQ 309 309 T -> TASKAESVCDGQAGQKTSEIQARGTKKKHLDSPRLG LAFRKFFRHK (in isoform 2) /FTId=VSP_018520 VAR_SEQ 381 394 Missing (in isoform 2) /FTId=VSP_018521 VAR_SEQ 451 472 Missing (in isoform 2) /FTId=VSP_018522 VAR_SEQ 584 584 K -> KYTGKCVFSHVKKKWPFQEWSY (in isoform 2). /FTId=VSP_018523 VARIANT 24 24 Q -> K (in dbSNP:rs394732) /FTId=VAR_026674 VARIANT 163 163 V -> A (in dbSNP:rs158551) /FTId=VAR_026675 VARIANT 255 255 G -> E (in dbSNP:rs6022903) /FTId=VAR_024251 VARIANT 472 472 Q -> H (in dbSNP:rs35575210) /FTId=VAR_050691 VARIANT 583 583 S -> P (in dbSNP:rs1055246) /FTId=VAR_026676 CONFLICT 361 361 G -> D (in Ref. 5; CAH18437) SEQUENCE 584 AA; 61709 MW; 22921C0B37129944 CRC64; MGNQMSVPQR VEDQENEPEA ETYQDNASAL NGVPVVVSTH TVQHLEEVDL GISVKTDNVA TSSPETTEIS AVADANGKNL GKEAKPEAPA AKSRFFLMLS RPVPGRTGDQ AADSSLGSVK LDVSSNKAPA NKDPSESWTL PVAAGPGQDT DKTPGHAPAQ DKVLSAARDP TLLPPETGGA GGEAPSKPKD SSFFDKFFKL DKGQEKVPGD SQQEAKRAEH QDKVDEVPGL SGQSDDVPAG KDIVDGKEKE GQELGTADCS VPGDPEGLET AKDDSQAAAI AENNNSIMSF FKTLVSPNKA ETKKDPEDTG AEKSPTTSAD LKSDKANFTS QETQGAGKNS KGCNPSGHTQ SVTTPEPAKE GTKEKSGPTS LPLGKLFWKK SVKEDSVPTG AEENVVCESP VEIIKSKEVE SALQTVDLNE GDAAPEPTEA KLKREESKPR TSLMAFLRQM SVKGDGGITH SEEINGKDSS CQTSDSTEKT ITPPEPEPTG APQKGKEGSS KDKKSAAEMN KQKSNKQEAK EPAQCTEQAT VDTNSLQNGD KLQKRPEKRQ QSLGGFFKGL GPKRMLDAQV QTDPVSIGPV GKSK
Citations (0)

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BCAS1 Antibody: BCAS1 was identified through positional cloning and was found to be overexpressed in most but not all breast cancer cells lines. Little is known about this protein; BCAS1 is cytoplasmically localized and is thought to form homodimers through coiled-coil structures. High levels of BCAS1 mRNA are seen in brain and prostate tissues, with lower amounts observed in colon, intestine and testis. Cells engineered to overexpress BCAS1 did not lose anchorage-dependent growth or increase their rate of growth, suggesting that BCAS1 is not a prototypical oncogene. The BCAS1 gene was also found to be amplified in other carcinomas such as pancreatic carcinoma, suggesting that BCAS1 may play in important role in the control of cell proliferation.


Collins C, Rommens JM, Kowbel D, et al. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. Proc. Natl. Acad. Sci. USA1998; 95:8703-8.
Beardsley DI, Kowbel D, Lataxes TA, et al. Characterization of the novel amplified in breast cancer-1 (NABC1) gene product. Exp. Cell Res.2003; 290:402-13.
Loukopoulos P, Shibata T, Katoh H, et al. Genome-wide assay-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome. Cancer Sci.2007; 98:392-400.

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$ 335.00
Cat# ASC11075
Availability: 5-7days
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