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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   EFHD2 Antibody   

EFHD2 Antibody

  • IHC - EFHD2 Antibody ASC11090
    Immunohistochemistry of EFHD2 in human brain tissue with EFHD2 antibody at 5 µg/mL.
  • IF - EFHD2 Antibody ASC11090
    Immunofluorescence of EFHD2 in human brain tissue with EFHD2 antibody at 20 µg/mL.
  • WB - EFHD2 Antibody ASC11090
    Western blot analysis of EFHD2 in mouse brain tissue lysate with EFHD2 antibody at (A) 1 and (B) 2 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96C19
Other Accession NP_077305, 20149675
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Application Notes EFHD2 antibody can be used for detection of EFHD2 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 79180
Target/Specificity EFHD2;
Reconstitution & Storage EFHD2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsEFHD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EFHD2
Synonyms SWS1
Function May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
Cellular Location Membrane raft. Note=In a mouse immature B-cell line WEHI-231.
Tissue Location Found in lymphocytes; preferentially expressed in CD8+ cells. EMBL; AL031283; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471167; EAW51720.1; -; Genomic_DNA EMBL; BC007233; AAH07233.1; -; mRNA EMBL; BC014923; AAH14923.1; -; mRNA EMBL; BC023611; AAH23611.1; -; mRNA EMBL; BC068473; AAH68473.1; -; mRNA CCDS; CCDS155.1; - RefSeq; NP_077305.2; NM_024329.5 UniGene; Hs.465374; - PDB; 5H0P; X-ray; 1.86 A; A=70-184 PDB; 5I2L; X-ray; 1.85 A; A=70-184 PDB; 5I2O; X-ray; 1.95 A; A=70-184 PDB; 5I2Q; X-ray; 1.94 A; A=70-184 PDBsum; 5H0P; - PDBsum; 5I2L; - PDBsum; 5I2O; - PDBsum; 5I2Q; - ProteinModelPortal; Q96C19; - SMR; Q96C19; - BioGrid; 122597; 47 IntAct; Q96C19; 7 MINT; Q96C19; - STRING; 9606.ENSP00000365147; - iPTMnet; Q96C19; - PhosphoSitePlus; Q96C19; - SwissPalm; Q96C19; - BioMuta; EFHD2; - DMDM; 20140139; - REPRODUCTION-2DPAGE; IPI00060181; - SWISS-2DPAGE; Q96C19; - EPD; Q96C19; - MaxQB; Q96C19; - PaxDb; Q96C19; - PeptideAtlas; Q96C19; - PRIDE; Q96C19; - ProteomicsDB; 76150; - TopDownProteomics; Q96C19; - Ensembl; ENST00000375980; ENSP00000365147; ENSG00000142634 GeneID; 79180; - KEGG; hsa:79180; - UCSC; uc001awh.2; human CTD; 79180; - DisGeNET; 79180; - EuPathDB; HostDB:ENSG00000142634.12; - GeneCards; EFHD2; - HGNC; HGNC:28670; EFHD2 HPA; HPA048961; - MIM; 616450; gene neXtProt; NX_Q96C19; - OpenTargets; ENSG00000142634; - PharmGKB; PA134942316; - eggNOG; KOG0041; Eukaryota eggNOG; ENOG4111JG9; LUCA GeneTree; ENSGT00390000012058; - HOGENOM; HOG000007978; - HOVERGEN; HBG051446; - InParanoid; Q96C19; - OMA; QYDAGKD; - OrthoDB; EOG091G106K; - PhylomeDB; Q96C19; - TreeFam; TF320736; - ChiTaRS; EFHD2; human GenomeRNAi; 79180; - PRO; PR:Q96C19; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000142634; - CleanEx; HS_EFHD2; - ExpressionAtlas; Q96C19; baseline and differential Genevisible; Q96C19; HS GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell GO; GO:0045296; F:cadherin binding; HDA:BHF-UCL GO; GO:0005509; F:calcium ion binding; IEA:InterPro CDD; cd00051; EFh; 1 InterPro; IPR011992; EF-hand-dom_pair InterPro; IPR002048; EF_hand_dom Pfam; PF13499; EF-hand_7; 1 SMART; SM00054; EFh; 2 SUPFAM; SSF47473; SSF47473; 1 PROSITE; PS50222; EF_HAND_2; 2 1: Evidence at protein level; 3D-structure; Acetylation; Calcium; Complete proteome; Direct protein sequencing; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat INIT_MET 1 1 Removed. {ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:22814378, ECO:0000269|Ref.4} CHAIN 2 240 EF-hand domain-containing protein D2 /FTId=PRO_0000073645 DOMAIN 92 127 EF-hand 1. {ECO:0000255|PROSITE- ProRule:PRU00448} DOMAIN 128 163 EF-hand 2. {ECO:0000255|PROSITE- ProRule:PRU00448} CA_BIND 105 116 1. {ECO:0000255|PROSITE- ProRule:PRU00448} CA_BIND 141 152 2. {ECO:0000255|PROSITE- ProRule:PRU00448} MOD_RES 2 2 N-acetylalanine {ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:22814378, ECO:0000269|Ref.4} MOD_RES 11 11 Phosphoserine MOD_RES 74 74 Phosphoserine MOD_RES 76 76 Phosphoserine MOD_RES 83 83 Phosphotyrosine {ECO:0000250|UniProtKB:Q9D8Y0} MOD_RES 233 233 N6-acetyllysine HELIX 82 85 {ECO:0000244|PDB:5I2L} HELIX 91 104 {ECO:0000244|PDB:5I2L} STRAND 109 112 {ECO:0000244|PDB:5I2L} HELIX 114 124 {ECO:0000244|PDB:5I2L} HELIX 130 140 {ECO:0000244|PDB:5I2L} STRAND 145 149 {ECO:0000244|PDB:5I2L} HELIX 150 161 {ECO:0000244|PDB:5I2L} HELIX 170 177 {ECO:0000244|PDB:5I2L} SEQUENCE 240 AA; 26697 MW; 9FE3FEC3007A8FC2 CRC64; MATDELATKL SRRLQMEGEG GGETPEQPGL NGAAAAAAGA PDEAAEALGS ADCELSAKLL RRADLNQGIG EPQSPSRRVF NPYTEFKEFS RKQIKDMEKM FKQYDAGRDG FIDLMELKLM MEKLGAPQTH LGLKNMIKEV DEDFDSKLSF REFLLIFRKA AAGELQEDSG LCVLARLSEI DVSSEGVKGA KSFFEAKVQA INVSSRFEEE IKAEQEERKK QAEEMKQRKA AFKELQSTFK
Research Areas
Citations (0)

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EFHD2 Antibody: EFHD2, also known as Swiprosin-1 or SWS1, is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology. EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLCgamma2-dependent B-cell receptor (BCR)-induced calcium flux. EFHD2 may also regulate BCR-induced immature and primary B-cell apoptosis. It controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Also, EFHD2 plays a role as negative regulator of the canonical NF-κB-activating branch.


Kroczek C, Lang C, Brachs S, et al. Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts. J. Immunol.2010; 184:3665-76.
Avramidou A, Kroczek C, Lang C, et al. The novel adaptor protein Swiprosin-1 enhances BCR signals and contributes to BCR-induced apoptosis. Cell Death Differ.2007; 14:1936-47.
Thylur RP, Kiim YD, Kwon MS, et al. Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway. J. Cell Biochem.2009; 108:705-15.

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$ 335.00
Cat# ASC11090
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