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IFITM1 Antibody

  • WB - IFITM1 Antibody ASC11149
    Western blot analysis of IFITM1 in 3T3 cell lysate with IFITM1 antibody at (A) 1 and (B) 2 µg/mL.
  • ICC - IFITM1 Antibody ASC11149
    Immunocytochemistry of IFITM1 in Jurkat cells with IFITM1 antibody at 20 µg/mL.
  • IF - IFITM1 Antibody ASC11149
    Immunofluorescence of IFITM1 in Jurkat cells with IFITM1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P13164
Other Accession NP_003632, 150010589
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 14 kDa

Observed: 14 kDa
Application Notes IFITM1 antibody can be used for detection of IFITM1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunocytochemistry starting at 20 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 8519
Target/Specificity IFITM1;
Reconstitution & Storage IFITM1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsIFITM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CD225, IFI17
Function IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.
Cellular Location Cell membrane; Single-pass membrane protein
Tissue Location Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines
Research Areas
Citations (0)

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IFITM1 Antibody: IFITM1 (Interferon inducible transmembrane protein 1) is a member of the IFN-inducible transmembrane protein family. It is an essential mediator of interferon-gamma-induced antiproliferation and plays a role in the control of cell growth. IFITM1 is upregulated in several tumor types and may be useful as a tumor biomarker. Both mouse IFITM1 and IFITM3 are expressed on the cell surfaces of primordial germ cells in a developmentally-regulated manner. IFITM1 activity is required for primordial germ cell transit, and IFITM1 acts as a repulsive molecule by repelling non-IFITM1-expressing primordial germ cells from the mesoderm into the endoderm.


Deblandre GA, Marinx OP, Evans SS, et al. Expression cloning of an interferon-inducible 17 kDa membrane protein implicated in the control of cell growth. J. Biol. Chem. 1995; 270:23860-6.
Yang G, Xu Y, Chen X, et al. IFITM1 plays an essential role in the antiproliferative action of interferon-gamma. Oncogene. 2007; 26:594-603.
Akyerli CB, Beksac M, Holko M, et al. Expression of IFITM1 in chronic myeloid leukemia patients. Leuk. Res. 2005; 29:283-6.
Tanaka SS, Yamaguchi YL, Tsoi B, et al. IFITM/Mil/Fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Cell 2005; 9:745-6.

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$ 335.00
Cat# ASC11149
Availability: 5-7days
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