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VENTX Antibody

  • WB - VENTX Antibody ASC11175
    Western blot analysis of VENTX in mouse brain tissue lysate with VENTX antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - VENTX Antibody ASC11175
    Immunohistochemistry of VENTX in rat brain tissue with VENTX antibody at 5 µg/mL.
  • IF - VENTX Antibody ASC11175
    Immunofluorescence of VENTX in rat brain tissue with VENTX antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95231
Other Accession NP_055283, 7657180
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Application Notes VENTX antibody can be used for detection of VENTX by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.
Additional Information
Gene ID 27287
Target/Specificity VENTX;
Reconstitution & Storage VENTX antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsVENTX Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HPX42B, VENTX2
Function May be involved in ventralization.
Cellular Location Nucleus.
Tissue Location Expressed in bone marrow of patients recovering from chemotherapy. Also expressed in an erythroleukemia cell line. EMBL; AF068006; AAC82375.1; -; mRNA EMBL; AF288039; AAK83043.1; -; Genomic_DNA EMBL; AL445199; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC108915; AAI08916.1; -; mRNA EMBL; BC108916; AAI08917.1; -; mRNA CCDS; CCDS7675.1; - RefSeq; NP_055283.1; NM_014468.3 UniGene; Hs.125231; - ProteinModelPortal; O95231; - SMR; O95231; - BioGrid; 118111; 15 IntAct; O95231; 89 STRING; 9606.ENSP00000357556; - iPTMnet; O95231; - PhosphoSitePlus; O95231; - BioMuta; VENTX; - PaxDb; O95231; - PRIDE; O95231; - ProteomicsDB; 50729; - DNASU; 27287; - Ensembl; ENST00000325980; ENSP00000357556; ENSG00000151650 GeneID; 27287; - KEGG; hsa:27287; - UCSC; uc010quy.3; human CTD; 27287; - DisGeNET; 27287; - EuPathDB; HostDB:ENSG00000151650.7; - GeneCards; VENTX; - H-InvDB; HIX0036778; - HGNC; HGNC:13639; VENTX HPA; HPA050955; - MIM; 607158; gene neXtProt; NX_O95231; - OpenTargets; ENSG00000151650; - PharmGKB; PA37803; - eggNOG; ENOG410J3ER; Eukaryota eggNOG; ENOG411280P; LUCA GeneTree; ENSGT00910000144024; - HOGENOM; HOG000154815; - InParanoid; O95231; - OMA; WLSQSSC; - OrthoDB; EOG091G0HNO; - PhylomeDB; O95231; - TreeFam; TF351607; - GenomeRNAi; 27287; - PRO; PR:O95231; - Proteomes; UP000005640; Chromosome 10 Bgee; ENSG00000151650; - CleanEx; HS_VENTX; - Genevisible; O95231; HS GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0043565; F:sequence-specific DNA binding; IMP:NTNU_SB GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IC:NTNU_SB GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB CDD; cd00086; homeodomain; 1 InterPro; IPR009057; Homeobox-like_sf InterPro; IPR017970; Homeobox_CS InterPro; IPR001356; Homeobox_dom Pfam; PF00046; Homeobox; 1 SMART; SM00389; HOX; 1 SUPFAM; SSF46689; SSF46689; 1 PROSITE; PS00027; HOMEOBOX_1; 1 PROSITE; PS50071; HOMEOBOX_2; 1 1: Evidence at protein level; Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Polymorphism; Reference proteome CHAIN 1 258 Homeobox protein VENTX /FTId=PRO_0000305938 DNA_BIND 91 150 Homeobox. {ECO:0000255|PROSITE- ProRule:PRU00108} VARIANT 42 42 L -> P (in dbSNP:rs2240892) /FTId=VAR_035243 VARIANT 79 79 M -> V (in dbSNP:rs2240891) /FTId=VAR_035244 VARIANT 101 101 E -> K (in dbSNP:rs2270192) /FTId=VAR_049591 VARIANT 191 191 G -> R (in dbSNP:rs9418952) /FTId=VAR_049592 VARIANT 247 247 G -> D (in dbSNP:rs9418953) /FTId=VAR_061269 SEQUENCE 258 AA; 27552 MW; 6F611169122D8244 CRC64; MRLSSSPPRG PQQLSSFGSV DWLSQSSCSG PTHTPRPADF SLGSLPGPGQ TSGAREPPQA VSIKEAAGSS NLPAPERTMA GLSKEPNTLR APRVRTAFTM EQVRTLEGVF QHHQYLSPLE RKRLAREMQL SEVQIKTWFQ NRRMKHKRQM QDPQLHSPFS GSLHAPPAFY STSSGLANGL QLLCPWAPLS GPQALMLPPG SFWGLCQVAQ EALASAGASC CGQPLASHPP TPGRPSLGPA LSTGPRGLCA MPQTGDAF
Citations (0)

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VENTX Antibody: Lymphoid-enhancing factor/T-cell factors (LEF1/TCF) are a high-mobility group of transcriptional factors that play essential roles in cell fate determination during early embryogenesis and ontogenesis. VENTX is a member of the Vent family of homeodomain proteins. It is a novel LEF/TCF-associated transcriptional modulator. VENTX is predominately expressed in hematopoietic cells. VENTX may function as a transcriptional repressor and be involved in mesodermal patterning and hemapoietic stem cell maintenance, and has been suggested to have a potential role in the hematopoietic malignancies.


Reya T and Clevers H. Wnt signalling in stem cells and cancer. Nature2005; 434:843-50.
Moretti PA, Davidson AJ, Baker E, et al. Molecular cloning of a human Vent-like homeobox gene. Genomics2001; 76:21-9.
Gao H, Le Y, Wu X, et al. VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor. Cancer Res.2010; 70:202-11.
Shtutman M, Zhurinsky J, Simcha I, et al. The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway. Proc. Natl. Acad. Sci. USA1999; 96:5522-7.

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$ 335.00
Cat# ASC11175
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