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NALP7 Antibody

  • IHC - NALP7 Antibody ASC11196
    Immunohistochemistry of NALP7 in human brain tissue with NALP7 antibody at 10 µg/mL.
  • IF - NALP7 Antibody ASC11196
    Immunofluorescence of NALP7 in human brain tissue with NALP7 antibody at 20 µg/mL.
  • WB - NALP7 Antibody ASC11196
    Western blot analysis of NALP7 in K562 cell lysate with NALP7 antibody at 2 µg/mL in (A) the absence and (B) the presence of blocking peptide.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WX94
Other Accession NP_631915, 46049100
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 111807 Da
Application Notes NALP7 antibody can be used for detection of NALP7 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 199713
Target/Specificity NLRP7;
Reconstitution & Storage NALP7 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsNALP7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP7
Synonyms NALP7, NOD12, PYPAF3
Function Inhibits CASP1/caspase-1-dependent IL1B secretion.
Tissue Location Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle.
Research Areas
Citations (0)

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NALP7 Antibody: NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1β secretion and is a feedback regulator of interleukin-1β secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.


Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
Kinoshita T, Wang Y, Hasegawa M, et al. PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion. J. Biol. Chem.2005; 280:21720-5.
Okada K, Hirota E, Mizutani Y, et al. Oncogenic role of NALP7 in testicular seminomas. Cancer Sci.2004; 95: 949-54.
Murdoch S, Djuric U, Mazhar B, et al. Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. Nat. Genet.2006; 38: 300-2.

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$ 335.00
Cat# ASC11196
Availability: 5-7days
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