|Application ||WB, E|
|Other Accession||Q8NF64, 54607108|
|Calculated MW||96537 Da|
|Application Notes||ZIMP7 antibody can be used for detection of ZIMP7 by Western blot at 0.25 - 0.5 µg/mL.|
|Target/Specificity||ZMIZ2; At least four isoforms are known to exist. ZIMP7 antibody is predicted to not cross-react with other PIAS protein family members.|
|Reconstitution & Storage||ZIMP7 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||ZIMP7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.|
|Cellular Location||Nucleus. Note=Detected at replication foci throughout S phase|
|Tissue Location||Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary|
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Provided below are standard protocols that you may find useful for product applications.
ZIMP7 Antibody: ZIMP7, also known as ZMIZ2, is a novel PIAS (protein inhibitor of activated signal transducer and activator of transcription)-like protein and a transcriptional coactivator. ZIMP7 is expressed most abundantly in testis. The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity and this activity is inhibited by the N-terminus in the full-length ZIMP7. ZIMP7 and the related protein ZIMP10 interact with PIAS3 and enhances Androgen Receptor (AR)- mediated transcription. The interaction between ZIMP7 and SWI/SNF complex suggests a possible role for ZIMP7 in chromatin modification.
Huang CY, Beliakoff J, Li X, et al. hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes. Mol. Endocrinol. 2005; 19:2915-29
Ueki N, Oda T, Kondo M, et al. Selection system for genes encoding nuclear-targeted proteins. Nat. Biotechnol. 1998; 16:1338-42.
Beliakoff J and Sun Z. Zimp7 and Zimp10, two novel PIAS-like proteins, function as androgen receptor coregulators. Nucl. Recept. Signal. 2006; 4:e017
Peng Y, Lee J, Zhu C, et al. A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription. J. Biol. Chem. 2010; 285:11465-75.
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