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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CCDC141 Antibody   

CCDC141 Antibody

  • WB - CCDC141 Antibody ASC11346
    Western blot analysis of CCDC141 in SK-N-SH cell tissue lysate with CCDC141 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide
  • IHC - CCDC141 Antibody ASC11346
    Immunohistochemistry of CCDC141 in mouse brain tissue with CCDC141 antibody at 5 µg/mL.
  • IF - CCDC141 Antibody ASC11346
    Immunofluorescence of CCDC141 in mouse brain tissue with CCDC141 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6ZP82
Other Accession NP_775919, 299829223
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 166261 Da
Application Notes CCDC141 antibody can be used for detection of CCDC141 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 285025
Target/Specificity CCDC141; At least four isoforms of CCDC141 are known to exist.
Reconstitution & Storage CCDC141 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsCCDC141 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCDC141
Synonyms CAMDI {ECO:0000303|PubMed:20956536}
Function Plays a critical role in radial migration and centrosomal function.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:A2AST1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:A2AST1}. Note=Co-localized with DISC1 at/around the centrosome. Localizes to the centrosome, at least in part, in a DISC1-dependent manner. {ECO:0000250|UniProtKB:A2AST1}
Research Areas
Citations (0)

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CCDC141 Antibody: Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1)-binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.


Fukuda T, Sugita S, Inatome R, et al. CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration. J. Biol. Chem. 2010; 285:40554-61.

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$ 335.00
Cat# ASC11346
Availability: 5-7days
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